Ozkan S, Murk W, Arici A (2008) Endometriosis and Infertility Epidemiology and Evidence-based Treatments. Best Pract Res Clin Obstet Gynaecol 18: 177-200. (2004) Endometriosis: epidemiology and aetiological factors. Vigano P, Parazzini F, Somigliana E, et al. (2008) MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Surgical phenotype data collection in endometriosis research. (2014) World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. (2017) The role of gene polymorphisms in endometriosis. Matalliotakis M, Zervou MI, Matalliotaki C, et al. Thambisetty M, Lovestone S (2010) Blood-based biomarkers of Alzheimer's disease: challenging but feasible Review. (2019) Genetics of endometriosis: a comprehensive review. doi: 10.1186/1477-īischoff F, Simpson JL (2004) Genetic Basis of Endometriosis. (2013) Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis. (1999) Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis. Taylor RN, Lundeen SG, Giudice LC (2002) Emerging role of genomics in endometriosis research. Genetic polymorphisms in eostrogen and progesterone receptor genes in Papio anubis induced with endometriosis during early stage of the disease. Waita, Atunga Nyachieo, Daniel Chai, Samson Muuo, Naomi Maina, Daniel Kariuki, Cleophas M. These findings suggest that genetic variants of eostrogen receptor 1 gene are related to susceptibility to endometriosis and therefore this warrants further investigation on how they influence the disease pathogenesis.Ĭitation: Irene M. Transition substitutions were more predominant than transversions in the eostrogen receptor 1 gene.
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There were two point mutations in progesterone gene although one had no effect on the amino acid sequence. Twenty-six point mutations in eostrogen receptor 1 gene resulted to a change in amino acid (non-synonymous mutations) while thirteen had no effect on the amino acid sequence (synonymous mutations). To determine the single nucleotide polymorphisms, the DNA sequences were analyzed using Bioedit software. DNA was extracted from thirty plasma samples and analyzed by direct sequencing using gene specific primers to determine polymorphisms in eostrogen receptor 1 and progesterone receptor genes. Female adult olive baboons (n = 10) were induced with endometriosis by intraperitoneal inoculation of autologous menstrual endometrium. The present study investigated the genomic variants in eostrogen receptor 1 and progesterone receptor genes in baboons with induced endometriosis. This hypothesis indicates the need for studies to identify the genes and genomic variants involved in the pathogenesis of endometriosis. The most common pathogenetic hypotheses is that there is possible dysregulation of the ligand-receptorial signaling involving the main sex hormones, eostrogen and progesterone.
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Genetic predisposition has been suggested to play a role in the pathogenesis of endometriosis.